The Marks lab is interested in investigating the regulation and diseases of intracellular protein transport and organelle biogenesis, the formation of functional amyloid in organelle biogenesis, regulation of antigen processing and innate immune signaling by endosomal trafficking pathways, melanosome maturation and the biology of platelet granules.
The laboratory is currently seeking self-motivated post-doctoral applicants to join the lab’s NIH-funded efforts on the biogenesis of melanosomes, the pigment-producing organelles in skin and ocular melanocytes. Our lab at Children’s Hospital of Philadelphia and the University of Pennsylvania employs cellular models of rare genetic diseases and collaborative efforts with mouse and human geneticists to dissect vesicular trafficking processes and transmembrane transporter function during the maturation of melanosomes and other cell type-specific organelles. Available projects include mechanistic analyses of BLOC function in membrane trafficking to and from melanosomes (using cellular models of Hermansky-Pudlak syndrome), mechanisms of organellar pH control by the products of oculocutaneous albinism genes and their interactors, and functional dissection of the products of novel human pigmentation genes. Successful applicants will have a Ph.D. in cell/ molecular biology or related fields and a strong background in cell biology, molecular biology, protein biochemistry, cellular physiology, and/or cutting-edge microscopy. Interested applicants should send a cover letter, CV, and the names of three referees to me at email@example.com. The Children’s Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, sexual orientation, age, religion, national or ethnic origin, disability or veteran status.
To learn more about Dr. Marks lab- click on the link below:
- Conduct independent scholarly research and develop new methods and protocols
- Participate in project planning, recording and evaluation of data
- Acquire technical, lab management and grant writing skills
- Participate in seminars, lectures, poster sessions and presentation at national meetings
- Supervise junior lab members
- Assist with other research projects