*Applications may be reviewed on a rolling-basis and this posting could close before the deadline. Click here for information about the selection process.
EPA Office/Lab and Location: A research opportunity is available at the Environmental Protection Agency (EPA), Office of Research and Development (ORD), Center for Computational Toxicology and Exposure (CCTE), Chemical Characterization & Exposure Division (CCED) located in Research Triangle Park, North Carolina.
Research Project: In this research program, high throughput methods are being developed and applied to determine what compounds humans are exposed to on a regular basis. This research will investigate select environmental media and complex mixtures for the multitude of chemicals of commerce, and prioritize confirming identities for those that have the highest potential for exposure and adverse outcomes. This research will extend the current capability for screening for ill defined chemicals and complex mixtures.
Throughout the course of this research project, the participant will be part of an EPA team of investigators who are identifying chemicals to which humans are exposed. The goal of this research is to identify individual components and classes of chemicals in a high throughput manner that people are exposed to on a daily basis. Research will include non-targeted and/or suspect screening analysis of environmental samples and substances of unknown or variable composition, complex reaction products, and biological materials (UVCBs) for identification of individual compounds and chemical classes to which humans are likely exposed.
Under the guidance of a mentor, participant research activities will include:
- Developing and applying instrumental methods to exposure relevant samples;
- Generating results and databases from exposure relevant samples screened via high resolution accurate mass (HRAM) mass spectrometry;
- Using and improving upon existing data analysis workflows;
- Interpreting large datasets (e.g., searching for trends, relevancy, patterns, etc.);
- Developing extraction and fractionation strategies that are the most appropriate for the majority of screening chemicals; and
- Sharing results via presentations and publications.
Learning Objectives: The participant will learn to apply their creativity and intellect toward solving complex problems and generating ideas for further investigation. The participant will also have the opportunity to further develop their technical skills, analytical capability, and communication skills. More specifically, the research participant will learn to develop scientific methods that allow for a more intuitive and informative high throughput analysis of samples from an exposure and/or risk context. The participant will also have opportunities to collaborate with other senior scientists who are experts in chemistry, biology, pharmacokinetics, biological modeling, statistics, informatics, toxicology, and risk assessment for supporting regulatory decision-making.
Mentor(s): The mentor for this opportunity is Elin Ulrich (firstname.lastname@example.org). If you have questions about the nature of the research please contact the mentor(s).
Anticipated Appointment Start Date: Winter 2021. All start dates are flexible and vary depending on numerous factors. Click here for detailed information about start dates.
Appointment Length: The appointment will initially be for one year and may be renewed up to three to four additional years upon EPA recommendation and subject to availability of funding.
Level of Participation: The appointment is full-time.
Participant Stipend: The participant will receive a monthly stipend commensurate with educational level and experience. Click here for detailed information about full-time stipends.
EPA Security Clearance: Completion of a successful background investigation by the Office of Personnel Management (OPM) is required for an applicant to be on-boarded at EPA.
ORISE Information: This program, administered by ORAU through its contract with the U.S. Department of Energy (DOE) to manage the Oak Ridge Institute for Science and Education (ORISE), was established through an interagency agreement between DOE and EPA. Participants do not become employees of EPA, DOE or the program administrator, and there are no employment-related benefits. Proof of health insurance is required for participation in this program. Health insurance can be obtained through ORISE.
Questions: Please see the FAQ section of our website. After reading, if you have additional questions about the application process please email EPArpp@orau.org and include the reference code for this opportunity.