*Applications will be reviewed on a rolling-basis.
Two postdoctoral fellowship opportunities are currently available in the Division of Biochemical Toxicology, National Center for Toxicological Research (NCTR) of the U.S. Food and Drug Administration (FDA) Jefferson Laboratories Campus located in Jefferson, Arkansas.
Research efforts will include participation in multi-disciplinary efforts in a nationally recognized training program in support of the FDA’s mission and be trained to conduct fundamental and applied research designed to elucidate mechanisms of toxicity and support risk-assessment for chemicals of interest to the FDA. The selected participant will be trained under Dr. Annie Lumen and her team on the development and use of pharmacokinetic and mechanistic models on projects in support of NCTR’s objectives and the FDA mission. Opportunities may include developing PBPK models for underrepresented life-stages to investigate and ensure the safety and efficacy of drugs repurposed for SARS-CoV-2 infection, characterizing life-stage specific variabilities to derive intra-population extrapolation strategies, and simulating drug-drug interactions of medications used concomitantly for treating COVID-19 which may differ from typical clinical trial participants based on specific life-stages. Through this fellowship, the selected participant will have the opportunity to learn and apply computational modeling skills, including life-stage PBPK modeling, local and global sensitivity analysis and population analysis, to address public health-related issues and gain experience in developing tools geared towards the advancement of regulatory science. S/he will collaborate with FDA investigators at NCTR and with investigators in other FDA centers such as the Center for Drug Evaluation and Research (CDER). During the project, s/he will be actively encouraged to present the research at internal and external meetings and publish the findings in peer-reviewed journals.
Anticipated Appointment Start Date: ~June 2021
If you have questions, send an email to ORISE.FDA.NCTR@orau.org. Please include the reference code for this opportunity (FDA-NCTR-2021-0005) in your email.